Our cell processing technology provides researchers with a powerful tool for MNC enrichment of blood and blood products with negligible residual red blood cell contamination.
Small Footprint, Big Results.
Next Level of Sophistication
The X-LAB® System is a sedimentation-based process that quickly and reliably isolates mononuclear cells without the need for density gradient media or manual transfer steps. Traditional separation methods are open, manual processes that inherently introduce the risk of contamination as well as cell loss due to the multiple tedious processing steps. Contrary to these methods, the X-LAB System provides consistently high MNC isolation quickly without the dependence on highly skilled laboratory personnel and is therefore cost-effective and provides the standardization needed in a busy processing facility.
Utilizing ThermoGenesis’ multi-sensor detection technology, the X-LAB® System precisely depletes the majority of red blood cells, granulocytes and platelets yielding a fully compartmentalized, volume reduced, MNC enriched fraction.
Quick and Efficient
Rapid enrichment of MNC in 35 minutes with the ability to process multiple units simultaneously.
Depletion and harvesting of cell fractions to their respective compartments is orchestrated by a specialized infrared sensor tower located within the Control Module of the X-LAB® System.
Processing data is captured for each and every procedure, providing superior traceability of all personnel, disposables and equipment used.
The X-LAB® System can be customized to accommodate a range of blood products, input volumes and programmed to provide user specific final product.
Complete System Solution
- X-LAB® Disposable Cartridge
- X-LAB® Control Module
- X-LAB® Docking station
- X-SERIES® DataTrak Software
Consistent, High Quality Results
- MNC recoveries consistently ≥ 90%
- Enrichment of MNC in ~35 minutes
- >99% RBC depletion
- Automated, sterile, closed system
- Reliable collection of all fractions: mononucleated cells red blood cells and plasma
- Quick and accurate data tracking and documentation
Disclaimers and Indications
ThermoGenesis Corp. X-SERIES® line of products such as the X-WASH® and X-LAB® System (Systems) are general purpose laboratory equipment labeled or promoted for a specific medical use, which are not subjected to pre-market clearance or approval by the US Food & Drug Administration (FDA). The safety and effectiveness of these devices for in vivo indications for use have not been established. Therefore, cells that are processed using these Systems that are intended for therapeutic use(s) or vaccine(s) may require advance clearance or approval by the U.S. FDA, which is the sole responsibility of the user.
The ThermoGenesis X-LAB® System is general lab equipment to be used to isolate target cells from blood and blood products.
The X-SERIES® Systems are now exclusively available for purchase through Corning Life Sciences. Learn more.
Working with the X-LAB® System
The X-LAB® System is an automated blood separation and concentration system with a sterile fluid path. The system uses a combination of disposable and electromechanical components to deplete red blood cells from the initial blood product and provide an MNC-enriched output.
The X-LAB® Control Module employs highly accurate sensors to separate the blood product in the Disposable Cartridge’s three chambers (central processing chamber, red blood cell depletion chamber, and harvest chamber) for maximum separation of components without the use of density gradient media.
Source material is transferred to the X-LAB® Disposable Cartridge via sterile welding or by a spike port. The 150-micron clot filter located on the input line allows for removal of clumps and promotes a single cell suspension for processing. After transfer, the input line is removed, then the Cartridge is attached to the X-LAB® Control Module, balanced with balanced with another Disposable and Control Module set or an X-Counterweight and X-Balance Ring accessories, and the Control Module is activated prior to centrifugation.
The X-LAB® System is used in conjunction with a commercially available linkable centrifuge that allows for optimal component stratification and separation. During centrifugation, the blood product is stratified, then red blood cells are transferred into the Disposable Cartridge’s depletion chamber, and the MNC fraction is delivered to a harvest chamber.
The harvested cellular fraction can be removed from the Disposable Cartridge by sterile welding to a transfer bag or by syringe.
White Papers, Abstracts & Presentations
- Sethi D, Ellis J, Contreras Z, Perea J, Truong S, and Miller J. Novel Buoyancy Based Cell Selection: X-BACS™ Technology. International Society for Cell and Gene Therapy (ISCT 2019), Montreal, Quebec.
- Fierro F, Lehmicke M, Ellis J, Perea J, Coelho, Cicchetto A, and Lee M. Recovery of Mesenchymal Stem and Endothelial Progenitor Cells from Reamer Irrigator Aspirator (RIA) Waste Fluid using the SynGenX™-LAB. International Combined Orthopaedic Research Societies (IORCS 2016), Orlando, FL.