AXP® II System
The innovative AXP II System defines the processing standard for harvesting stem cells from umbilical cord blood units. It’s an automated, fully closed, sterile system that volume-reduces cord blood to a user-defined volume in 30 minutes, while retaining over 97% of the mononuclear cells (MNCs)*. Self-powered and microprocessor controlled, the AXP II System contains flow control optical sensors which achieve precise separation.
HANDS-FREE OPERATION • Automated, closed, sterile system.
HANDS-FREE OPERATION • Automated, closed, sterile system.
RELIABLE VOLUME REDUCTION • Reproducible reduction of initial unit volume to a user-determined final volume allows standardization of the freezing process.
STREAMLINES WORKFLOW • Simultaneous processing of up to six samples.
SAFE OPERATION • In-line sterile sampling.
EASY DATA MANAGEMENT • Quick and accurate data tracking with XpressTRAK® software.
SELF-POWERED • Powered by a rechargeable NiMH battery.
COMPLETE SYSTEM SOLUTION • The AXP II consists of the AXP II device, docking station, processing set, and XpressTRAK® software that assists with cGMP and cGTP compliance.
For ordering information, contact us!
Cord blood is transferred from a standard collection bag to the processing set, which is placed in the AXP II device and centrifuged.
After centrifugation the blood is stratified into red blood cell, buffy coat, and plasma segments. The AXP II device harvests each of these components into separate bags.
Brochures
Raising the Standard on Cord Blood Processing
The AXP® II System has been designed to provide high-quality stem cell concentration from cord blood. So when you are processing cord blood samples, using the AXP® II System, you can be confident that you are isolating and saving the highest concentration of stem cell rich buffy coat while retaining their viability.
Automation at its Finest
Cord blood is transferred into the processing bag set which is placed in the AXP Device and then centrifuged. The AXP Device fits into most standard blood bank centrifuge buckets allowing up to six samples to be processed simultaneously. During centrifugation, component stratification and separation occurs. Red blood cells (RBC) are transferred to a separate sterile bag, the buffy coat which contains the mononuclear cell (MNC) rich layer is delivered to a separate sterile freezing bag while the plasma remains in the processing bag. The AXP II System does not require the addition of hetastarch for successful capturing of MNCs.
Quality Results.
The AXP II System offers high quality product with a precise delivery of the final target volume. The AXP II delivers competitive TNC recoveries with consistently high MNC recovery. The process maintains a stable environment for the CD34+ cells granting the final product the highest possible viability. The precision control gives a consistent ~30% Hematocrit in the final product.
| Cell Population | Pre-Process (Cord Blood) | Post-Process (Harvest MNC Fraction) | % Recovery |
| Total Nucleated Cells x 106 | 1150 ± 273.4 | 969 ± 225.3 | 84.8 ± 9.2 |
| Total Mononuclear Cells x 106 | 453 ± 134.6 | 442 ± 126.6 | 97.9 ± 4.9 |
| Total CD34+ Cells x 103 (%Viable) | 3364 ± 1594.0 (99.7 ± .03) | 3256 ± 1412.7 (99.8 ± .02) | 98.2 ± 8.0 |
| CFU x 106 | 2.6 ± 1.1 | 2.5 ± 1.0 | 94.6 ± 7.0 |
Indications.
The AXP II System is a second-generation cord blood processing system and is part of the ThermoGenesis line of products. It is intended for laboratory use in combination with a specific and compatible single-use separation kit. The AXP II System allows the fast, automated, and reproducible separation of cord blood in a closed and sterile environment.