BioArchive® System

The BioArchive® System is the only fully robotic storage and retrieval system for cryopreserving high value cell samples.

Insurance Today, For a Viable Future.

By using a proven, computer-controlled technology and tracking software, the BioArchive provides the best protection for today’s high value cell samples that meet tomorrow’s stem cell therapy needs.

  • Samples are stored at a consistent -196°C temperature

  • Constant temperature control through closed-system sample handling with robotic storage and retrieval

  • Integrated control rate freezing

  • Delivers up to 94% post-thaw cell viability1*

  • Individual storage and retrieval of cell samples results in minimal exposure to transient warming events (TWE)

  • Automated tracking of individual sample freeze curves and storage in LN2 assures maximum confidence

Superior Design. Unsurpassed Viability.

  • Viable CD34+ stem cell recovery is consistently > 97%, higher than other available systems1

  • Fully automated, closed system maintains cell integrity

  • Precise robotic storage and retrieval minimizes TWE

  • Over 3600 sample capacity

Complete System Solution

The BioArchive® System consists of the following key components:

  • Liquid nitrogen dewar with storage rack

  • Liquid nitrogen control system for the dewar

  • Controlled rate freezer (CRF) modules

  • Sample retrieval cartridge

  • Robotic arm consisting of a barcode reader and a periscope with a canister hook necessary for storage and retrieval

  • Microprocessor control system which controls the automated functions and maintains records of the samples freeze profile and system inventory

  • Sample Management Software (SMS)

  • Computer and accessories (printer, barcode label scanner, barcode label printer, mouse, keyboard, laptop)

  • One magnetic retrieval device

Controlled Freezing. Confident Results.

  • Controlled-rate freezing process, a sensor monitors the sample temperature

  • This individual controlled-rate freezing maintains the sample’s cell integrity during the freeze cycle

  • The CRF controls the rate of freezing based on temperature and time until the sample reaches -50°C

  • Once the sample reaches -50°C it is then moved from the CRF and is placed in an unique location for storage. It can then be independently retrieved without compromising other samples cell viability

  • Three-dimensional, 25mL, dual-compartment blow-molded freezing bag and a stainless-steel canister ensures precise, uniform freezing

  • An overwrap bag adds further sample protection during storage in LN2

Tracking with Certainty. Storing with Confidence.

  • Software provides accurate, individualized, fully documented freeze and sample tracking, history, and inventory

  • Robotic arm retrieves sample via integrated barcode reader

  • Data acquisition storage information is accessed via the sample’s unique barcode

  • Software helps comply with cGMP and cGTP Requirements

Safety for Samples. Safe for the Operator. 

  • Multiple safety controls protect cell preservation and operator

  • Magnetic stainless-steel canisters firmly house overwrapped freezing bags, enabling precise robotic insertion, and retrieval from liquid nitrogen

  • Vacuum-insulated Dewar helps maintain constant temperatures and a safe environment

  • Robotic arm identifies and retrieves only the desired sample, protecting all other samples from TWE

  • Robotic functions and minimal dewar access points reduce operator exposure to liquid nitrogen

  • Insulated retrieval cartridge helps protect handler from exposure to liquid nitrogen and samples to TWE

  • Uninterrupted power supply

  • Liquid nitrogen volume control alert system

  • Series of audible alarms and screen alerts notify users of situations that need to be attended to.

Video

References

  1. Rubenstein P. Cord blood banking for clinical transplantation. Bone Marrow Transplantation 2009;44:635-642.

* When used in conjunction with the AXP® System.